Dose-ranging studies are an important component of preclinical testing for new drugs, chemicals, and other substances. These studies aim to determine the appropriate dosage range for the substance, and to identify any potential adverse effects of the substance at different doses.

The primary objective of dose-ranging studies is to determine the optimal dose range for the substance, which maximizes efficacy while minimizing toxicity. These studies typically involve the administration of the substance at different doses to laboratory animals, and the evaluation of its effects on a range of endpoints, such as pharmacokinetics, pharmacodynamics, and toxicity.

Dose-ranging studies can be conducted using a range of routes of administration, including oral, intravenous, or inhalation. These studies typically involve the administration of the substance at several doses, with each dose tested in a separate group of animals. The dose range tested in dose-ranging studies is typically broader than that tested in subsequent studies, such as efficacy or safety studies.

The results of dose-ranging studies can help inform the design of subsequent studies, such as efficacy or safety studies. For example, dose-ranging studies can help identify the appropriate dose range for subsequent efficacy studies, and can help determine the maximum tolerated dose for subsequent safety studies. These studies are an important part of the preclinical safety and efficacy assessment of drugs and other substances, and are required by regulatory agencies before clinical testing in humans can be initiated.