Toxicology GLP | Preclinical Study

The selection of appropriate endpoints for preclinical studies is critical to ensure the safety and efficacy of new drugs, chemicals, and other substances. Endpoints are the measurable parameters used to evaluate the effects of a substance on the animal or cellular system under investigation. The selection of endpoints should be based on the substance’s intended…

Therapeutic index assessment is a critical component of preclinical testing for new drugs, chemicals, and other substances. The therapeutic index is a measure of the safety and efficacy of a substance, calculated as the ratio of the dose required to produce a therapeutic effect to the dose that produces toxic effects. The primary objective of…

Dose-ranging studies are an important component of preclinical testing for new drugs, chemicals, and other substances. These studies aim to determine the appropriate dosage range for the substance, and to identify any potential adverse effects of the substance at different doses. The primary objective of dose-ranging studies is to determine the optimal dose range for…

Safety pharmacology studies are a critical component of preclinical safety assessment for new drugs, chemicals, and other substances. These studies aim to evaluate the potential adverse effects of a substance on vital physiological systems, such as the cardiovascular, respiratory, and central nervous systems, before clinical testing in humans. The primary objective of safety pharmacology studies…

In vivo toxicology studies are an important part of preclinical assessment for new drugs, chemicals, and other substances. These studies involve the use of laboratory animals to evaluate the potential toxic effects of a substance before it is tested in humans. The primary objective of in vivo toxicology studies is to identify any potential adverse…

In vitro toxicology studies are a critical part of preclinical assessment of new drugs, chemicals, and other substances. These studies involve the use of laboratory cell cultures or tissues to evaluate the potential toxic effects of a substance before it is tested in animals or humans. In vitro studies are cost-effective and provide a rapid…

Histopathology and histomorphometry are important tools used in preclinical studies to evaluate the effects of a substance on tissue structure and function. These techniques involve the examination of tissue samples obtained from animals that have been exposed to the substance of interest. Histopathology involves the microscopic examination of tissue samples to identify any morphological changes,…

Renal toxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the kidneys and urinary system. These studies are typically conducted in laboratory animals, such as rats, mice, or dogs, to assess the safety of a drug or other substance before testing in humans. The primary objective…

Cardiovascular toxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the cardiovascular system. These studies are typically conducted in laboratory animals, such as rats, mice, or dogs, to assess the safety of a drug or other substance before testing in humans. The primary objective of cardiovascular…

Pulmonary toxicity studies are preclinical studies that are conducted to evaluate the potential adverse effects of a substance on the respiratory system, including the lungs and airways. These studies are typically conducted in laboratory animals, such as rats, mice, or dogs, to assess the safety of a drug or other substance before testing in humans.…